The Exercise of Accounting Clothes Personal Statement - 2

The Exercise of Accounting Clothes - Personal Statement Example I thought that I had only few purchases that were made from China but I did not expect that majority of them were actually from China (there were 22 clothes that I bought coming from them). This misimpression is due to the fact that even if the brand is patently American, if we bother enough to check the label on where it is made, it is in fact made in China. For example, my sport apparel Nike. We know that Nike is an American company and we would like to think that it is also made in America. But no, check the labels and you cannot even read them because it is written in Chinese character. It is in fact made in China. This led me to think and do some basic research. I begun to understand the supply chain that companies employ in order to save cost and become competitive. But again, this led me to think if the main motivation really is to save on cost to sell their products more affordable then are their prices are saying otherwise? Nike is still priced at premium even if they had ou tsourced their manufacturing to some sweatshops in China. These companies are raking billions of dollars in profit. The motivation of having their manufacturing somewhere else must be the drive to profit more by finding ways to cut cost by looking for people who can do the job the cheapest way possible. Sadly, this takes jobs away from Americans and kills our local garment industry. This also makes the salary of those who works in our textile industry low because of competition of the dirt cheap salary of textile workers in Bangladesh and Cambodia. Worst, this outsourcing has brought new evils in the country that they were outsourced such as China and countries in South East Asia (Thailand, Indonesia, Philippines). News about the old labor, unreasonably long working hours and dangerous working conditions are prevalent that it defeats the benefit of giving people jobs because they are being exploited. Also, the quality of the textiles deteriorates because the manufacturing process of the countries they are from cut corners. Also, I noticed during the process of my accounting my clothes that some have labels of being recyclable (the ones made in USA) while many do not. I understood it because of our stringent laws about the environment and our general concern about the environment. I checked the labels on the other clothes that I have that were made overseas and there were no labels that the clothes can be recycled. This led me to think that these manufacturers must have no concern for the environment after making the sales or even during the manufacture of these clothes. Come to think of it, if they cared less about their workers, employing them in hazardous working conditions and giving them oppressive salaries whose ill effects can be immediately observed, how much more about the environment whose effect can only be felt many years ahead? Also, the quality of the fabric can readily be distinguished because those that came from the USA are noticeably of better quality. We just came from a financial crisis and to some extent, we are still reeling from it.

Finance assignment1 Essay Example | Topics and Well Written Essays - 2250 words

Finance assignment1 - Essay Example 64400 36000 28400 Since the least payment to be paid by Alresford to Gibson under third option, i.e., 28400, it is advisable to go ahead with third option. (d) Under Imputation system, the tax payable by the company is deductible for the tax computation of shareholders. The imputation system, when the company's tax is avoided the calculation will be as follows: Operating cash flow north south total cost of capital market value 12000 12000 24000 18% 4320 12000 8000 20000 18% 3600 16000 8000 24000 18% 4320 20000 4000 24000 18% 4320 PART B The Cost and Benefits of Debt Introduction Among the various sources of capital, debt is an important and popular source of long term fund for small as well as big firms. Other sources include equity and preference shares and retained earnings. Debt is a long term arrangement with a lender by a company to avail finance on a certain set of conditions. The lender may be banks and financial institutions, public, and other corporations issuing debt securities. The company can avail debt capital in various forms such as bonds, long term loans from banks and financial institutions etc. Bond is the most common form of debt security issued by a corporation. Bonds are issued by governments also in time of financial crisis. Debt is the least cost and hence the most popular source of capital for corporations. In addition to that it has many advantages. As bonds are the common form of debt capital, bonds and debt are often used interchangeably. Moreover, the attributes of bonds as a source of long term capital are similar to any other de bt capital. Therefore, the following discussion of cost and benefits of debt is common to bonds and long term loans. Cost of Debt Debt is a long term agreement with a lender (bank or public) by a...The company can avail debt capital in various forms such as bonds, long term loans from banks and financial institutions etc. Bond is the most common form of debt security issued by a corporation. Bonds are issued by governments also in time of financial crisis. Debt is the least cost and hence the most popular source of capital for corporations. In addition to that it has many advantages. As bonds are the common form of debt capital, bonds and debt are often used interchangeably. Moreover, the attributes of bonds as a source of long term capital are similar to any other debt capital. Therefore, the following discussion of cost and benefits of debt is common to bonds and long term loans. Debt is a long term agreement with a lender (bank or public) by a company to avail funds on the condition that interest shall be paid by the latter to the former during the period of debt and the principal shall be paid at the end of maturity period. The interest to be payable by the company to the lender is known as the cost of debt. In other words, cost of debt is the interest payable by the company to the lender for using the latter's hard earned money. The interest payment is to be made annually or semi-annually depending upon the terms of agreement.

Systems To Involve Stakeholders In The Planning Change Management Essay

Systems To Involve Stakeholders In The Planning Change Management Essay Prior to implementing a companywide change, it is important to get stakeholders on board. Organisations take their stakeholders into confidence, just to ensure the smooth transition, since they are the one who will be affected by the change. For an organisation stakeholder can be its employees, customers, suppliers, shareholders, managers, government, local community, creditors etc. n order to achieve this goal, stakeholder analyses are carried out. Stakeholder Analysis The process of identifying those who will be affected by the actions of organisation. It also enables the managers to analyze the attitudes of stakeholders towards the change. In order to carry out these analysis, following steps are taken: Identify the stakeholders in stakeholder analysis the first step is to come up with the list of any who will be affected by the organisational actions, this can include an individual, a group or an organisation. The possible stakeholders for Gill Construction can be: new Managing Director previous MD senior managers suppliers lenders / banks customers public future recruits, environment protection groups regulatory bodies Prioritize your stakeholders For organisations the list of stakeholders can be very long, in one case of university 20,000 stakeholders were identified. This doesnt mean that everyone is very important to the organisation. Hence the next step in stakeholder analysis is to prioritize stakeholders. This can be done using Power / Interest Grid. Using this grid, Gill construction can identify their key stakeholders, which can be: new Managing Director senior managers suppliers lenders / banks customers public environment protection groups and regulatory bodies existing workforce Stakeholder analysis strategy Understand Your Key Stakeholders this is the last step in stakeholder analysis. It focuses on understanding the key stakeholders, and defines the way they will be affected. It also highlights the interests stakeholders have with the organisation. It answers the following question: What financial or emotional interest do they have in the outcome of change? Is it positive or negative? What motivates them? What information do they want? How do they want to receive information? What is the best way of communicating with them? What is their current opinion? Is it based on good information? Who influences their opinions generally? Do some of these influencers therefore become important stakeholders in their own right? If they are not likely to be positive, what will win them around to support change? How to manage their opposition How they can influence others by their opinion? Convergence and Divergence Another model adopted by management gurus to analyze the stakeholders. It enables the managers to identify the factors which are opposing the stakeholders and which are supporting it. Divergence analysis of the factors which are opposing the change for stakeholders. The first step is to identify the basic change factors which are causing the opposition, these can be beliefs, values, and goals associated with the stake holders. Managers need to answers like What are their beliefs about change and which have led them to oppose it? What are the values being transgressed by change actions? Are their stress values being triggered? How is the change affecting their career social goals? Managers also need into their perception of the change, analyzing this can give them huge edge converting their opposition. They need to answer questions like What do they think about change? What do they think will happen? How do they look at other stakeholders? Convergence elements which are supporting the change. It is much focused on those who oppose the change. Managers need to understand who they are dealing with, what they are capabable how and how they can affect them. For-example A regulatory body or HSE will have permission to shut down the work in progress if they find anything in violation of the laws. Also in case of Supply chain, they may also ruin their relationship with the supplier. Banks and Lenders will have their leverage over the organisation since a loan was taken for the purchase of new machinery. Managers need to look into the following cases: How the stakeholder will be managed? Do they need any leadership or they will just follow? What made them follow the leadership How will they support the change? How prepared are they for the change? Evaluate the systems used to involve stakeholders in the planning of change Stakeholders Circle: A tool designed to gain stakeholder commitment and involve the key stakeholders in developing a change management strategy. This cycle has six steps and also known as Six Steps Stakeholders Cycle Identify the stakeholders The first step is to identify the key stakeholders, which can influence and have interest within the organisation. Prioritize the stake holders Managers need to identify the key stakeholder using the Power-Interest Grid. For Gill Construction these key stakeholders are : MD Employees Management Customers Suppliers Regulatory Bodies Map the Profile next step is to map the profile, how will they be affected, what is in the change for them, how they can be supported, what kind of support we can get from them, what are their culture and values. All the questions will be answered at this point Engagement strategy At this point a managers need to decide how they are going to address the issues of stakeholders in order to gain their commitment and support. New MD of Gill Construction need to hold a meeting with management of the company. Clearly define what He wants to achieve and what his goals are. Since his goal is to improve the quality of the work done and also expand the business. It will be then the job of Management to directly contact their respective staff members and explain the situation to them. Ideas for improvement will be taken. Meeting and Presentations will be held with suppliers and explain your objective to them. Also Management will seek advice from regulatory bodies to assists them in improving the H S at workplace. Banks and Lenders will also be taken into confidence. A clear business plan will be presented to them. Optimise their Support next step in this cycle is to optimise the support from stakeholders. Managers need to be very clear and specific about their objective to the stakeholder and try to get most out of them. They need to keep good relationships with their lenders/ banks and suppliers. Monitor the last and final stage is to monitor the strategy. They need to keep going back to their stakeholders and ensure their support is still with them. If they have any kind of doubts they need to clear them out. Develop a change management strategy with stakeholders A strategy will be formed which will help management at Gill Construction to gain commitment from their stakeholders. A general change management strategy involves three steps: Situational awareness before a companywide change is implemented, everyone will be made aware of the change and what is going to happen in result of this change. A vision will be created Stakeholders will be informed that how this will effect. Suppliers will be notified about what will be expected of them. Employees will be taken into confidence to avoid panic. Supporting structures second step is to structure teams and sponsor coalition. They will be debriefed about who is going to do what. If they will be let go off, they will be informed at this stage. They will be informed that they need to trained to operate the new machinery. Bank or Lender will be informed about new purchases and equipment. New policy about H S will be sent to HSE and they will be informed about it. Suppliers will be contacted and new terms regarding JIT will be set, also material price will be revisited.   Strategy analysis this stage involves risk analysis to be carried out. what degree of risk is involved in this change. What will happen if this strategy fails. In case there is no progress even after this change, what will we do, what if lenders refuse to pass a load. In case of resistance from stakeholders a resistance to change strategy will be required. Management will give their best to negotiate on good terms with the suppliers and use the bargaining power. Management also need to convince the bank and lenders to pass the load and take them into confidence. Create a strategy for managing resistance to change It is in human nature that whenever they are asked to move out of their comfort zone or change, they resist it. When organisations go under change it is very obvious that stakeholders will be afraid of its outcome. Hence it is very important to manage this resistance because this resistance can raise the risk factor during the change or transition process. Passive versus Active Resistance A framework adopted from Active Passive Being critical Agreeing verbally but not following through Ridiculing failing to implement change Appealing to fear Procrastinating or  dragging one feet Using facts selectively Feigning ignorance Blaming or accusing Withholding information, suggestion, help or support Intimidating or threatening Standing by or allowing change to fail Manipulating Blocking Starting rumours Arguing Managing Resistance Before a change is implemented it is very important for managers to either eliminate resistance completely or bring it down to a very lower level such that it has a very minor effect. There can be number of ways for managing this resistance. Some of the ways adopted by Gill Construction can be: Communication everyone within the organisation should be made aware of the situation. Managers need to communicate openly with all the stakeholders and discuss the issues with them. Even if they are supporting the change management need to check with them back to back to ensure the full commitment. Management need to hold meetings, brainstorming session with the staff and communicate with them. Suggestions will be taken from the staff and their participation will be encouraged. Training staff will be provided with appropriate training to build up their skills so that they can operate the new machinery. This will help to eliminate the resistance put up by the operational workforce. Also work-shops will be held with other staff to ensure that they are not left behind. They will be provided with the information and steps involved in this transition will be explained to them. Feedback Taking feedback or suggestions from the stakeholders is always the best way to gain their commitment. This shows to them that management is still listening to them and they hold a value to them. Taking feedback about the training is also good to monitor the staff performance.

Distance Learning Essay -- Essays Papers

Distance Learning Many institutions of higher education are experimenting with changes having to do with class offerings. According to Keegan, â€Å"It is not easy to define distance education.† An early descriptive definition states that distance education learners are usually taught as individuals and not in groups (Rossman 8). Distance education can be thought of as instructional delivery that does not constrain the student to be physically present in the same location as the instructor. Distance learning is a newly emerging trend that many institutions are taking advantage of. At the present, this type of learning is primarily used for those people who cannot attend courses on a campus. Distance learning is just another sign pointing towards the emergence of a worldwide electronic university. Through these programs, institutions are creating truly â€Å"global classrooms.† In today’s technologically advanced society, the term â€Å"classroom† has a new meaning. In distance learning, one’s classroom could consist of a television classroom, a â€Å"virtual classroom,† a teleconference, a â€Å"virtual reality† classroom, and others. The traditional classroom is being substituted for classrooms that accommodate each different distance-learning program. Virtual classrooms take place on the computer and can be accessed anywhere. Teleconferences take place on the telephone. On-line courses are held anytime on-line, which makes it easier for the student taking the course. Another form of distance education is visual learning, which includes using video systems and broadcast television. Television broadcasts are used for one-way video and audio presentations. Radios and tapes can also allow the student to listen to lectures one way and audio-... ... to the educating of today’s society. Distance learning is thought to be able to increase global unity, create an easier, less stressful way to receive a quality education, and overall create a greater passion for learning(Rossman 138). Works Cited Hodgson, Vivien E, Sarah J. Mann, and Robin Snell. Beyond Distance Teaching-Towards Open Learning. Philadelphia:Open University Press, 1987. 1-181. Kennedy, Kristen. â€Å"Intellectual Property in the Digital Age.† Technology and Learning 22(2001):8 Porter, Lynette R. Creating the Virtual Classroom:Distance Learning with the Internet. New York: John Wiley and Sons Inc.,1997.1-83 Rossman,Parker.The Emerging Worldwide Electronic University:Information Age Global Higher Education.Connecticut:Greenwood Press, 1992.1-89. â€Å"The Army Marches Into Online Learning.† Black Issues in Higher Education 24(2001):17

Sci 241 Week 5

( ©Reinhard/Age Fotostock America, Inc. ) CHAPTER 8 CONCEPTS I I I I I I I I I Thiamin, ribo? avin, niacin, biotin, and pantothenic acid are B vitamins needed to produce ATP from carbohydrate, fat, and protein. Vitamin B6 is important for amino acid metabolism as well as energy production. Folate is a coenzyme that is needed for cell division. Vitamin B12, only found in animal foods, is needed for nerve function and to activate folate. Vitamin C is needed to form connective tissue and acts as a watersoluble antioxidant. Vitamin A is essential for vision, and it regulates cell differentiation and growth. Vitamin D is necessary for bone health. Vitamin E is a fat-soluble antioxidant. Vitamin K is essential for blood clotting. u s t A Ta s t e J Do vitamins give you extra energy? Should everyone take folate supplements? Does eating carrots improve your vision? Can vitamin E protect you from heart disease? The Vitamins Vitamins Are Vital to Your Health Vitamins Provide Many Different Functions in the Body Vitamins Are Found in Almost Everything You Eat We Need Enough but Not Too Much of Each Vitamin Some Vitamins Are Soluble in Water and Others Are Soluble in Fat Many B Vitamins Are Essential for Energy Production Thiamin: Important for Nerve Function Ribo? vin: A Bright Yellow Vitamin Niacin: De? ciency Caused an Epidemic of Mental Illness Biotin: Eggs Contain It but Can Block Its Use Pantothenic Acid: Widely Distributed in Food and Widely Used in the Body Vitamin B6 Is Important for Protein Metabolism Vitamin B6 Is Needed to Synthesize and Break Down Amino Acids Both Animal and Plant Foods Are Good Sources of Vitamin B6 Too Much Vitamin B6 Is Toxic Folate and Vitamin B12 Are Needed for Cell Division Folate: Important for Rapidly Dividing Cells Vitamin B12: Absorption Requires Intrinsic Factor Vitamin C Saved Sailors from Scurvy Vitamin C Is Needed to Maintain Connective Tissue Vitamin C Is a Water-Soluble Antioxidant Citrus Fruit Is One of the Best Sources of Vitamin C Vitamin C Is the Most Common Vitamin Supplement Choline: Is It a Vitamin? Vitamin A Is Needed for Healthy Eyes Vitamin A Comes in Preformed and Precursor Forms Vitamin A Requires Fat for Absorption and Protein for Transport Vitamin A Is Necessary for Vision Vitamin A Regulates Gene Expression -Carotene Is a Vitamin A Precursor and an Antioxidant Vitamin A Needs Can Be Met with Plant and Animal Sources Vitamin A De? iency Is a World Health Problem Preformed Vitamin A Can Be Toxic Vitamin D Can Be Made in the Skin Vitamin D Is Needed to Maintain Normal Calcium Levels Vitamin D De? ciency Causes Weak Bones Only a Few Foods Are Natural Sources of Vitamin D Too Much Vitamin D Causes Calcium to Deposit in the Wrong Tissues Vitamin E Protects Membranes Vitamin E Is a Fat-Soluble Antioxidant Vitamin E De? ciency Damages Membranes Most of the Vitamin E in Our Diets Comes fr om Plant Oils Vitamin E Is Relatively Nontoxic Vitamin K Is Needed for Blood Clotting Vitamin K De? iency Causes Bleeding Drugs That Inhibit Vitamin K Prevent Fatal Blood Clots The Requirement for Vitamin K Is Met by Bacterial Synthesis and Food Sources 8 INTRODUCTION Vitamin D Concerns on the Rise By Karen Collins, R. D. Dec. 5, 2003—A lack of vitamin D—thought to be a problem of a bygone era—is showing up in growing numbers of women, children, and the elderly, increasing the risk of bone disease and possibly other health problems. Exposing only the face, hands, and forearms to sunlight for 10 to 30 minutes, just two or three days a week, can usually produce all the vitamin D we need. Longer exposure doesn’t produce more of this vitamin. Yet today, many people’s lifestyles and locations do not allow them to produce enough, making dietary sources vital. For more information on vitamin D concerns go to www. msnbc. msn. com/id/3660416. A ren’t vitamin de? ciency diseases a thing of the past? After all, the vitamins have been identi? ed, characterized, and puri? ed. We get them from foods that are natural sources and they are added to our breakfast cereal and sold in pill form. For over 100 years scientists have been experimenting with how much of which ones we need to stay healthy and public health of? ials have been providing us with guidelines as to how best to get enough from our diets. How can anyone have a de? ciency? Despite advances in vitamin research over the last century, millions of people around the globe still suffer from vitamin de? ciency diseases. In the United States, the plentiful and 235 236 Chapter 8 The Vitamins varied food s upply make severe vitamin de? ciencies unlikely but this doesn’t mean everyone gets enough of everything all the time. Marginal de? ciencies often go unnoticed and can be mistaken for other conditions. Vitamins Are Vital to Your Health L Vitamins Organic compounds needed * in the diet in small amounts to promote and regulate the chemical reactions and processes needed for growth, reproduction, and the maintenance of health. Vitamins are essential to your health. You only need very small quantities but if you don’t get enough your body cannot function optimally. Severe de? ciencies cause debilitating diseases but even marginal intakes can cause subtle changes that affect your health today and your risk of chronic disease tomorrow. An organic substance is classi? ed as a vitamin if lack of it in the diet causes symptoms that are relieved by adding it back to the diet. The fact that the vitamins we eat in food are essential to health seems simple and obvious, but it was not always so. For centuries, people knew that some diseases could be cured by certain foods. But it was a long time before we understood why particular foods relieved speci? c ailments. Cures attributed to foods seemed like nothing short of a miracle. People too weak to rise from their beds, those with bleeding wounds that would not heal, those too mentally disturbed to function in society, and those with other serious ailments were cured with changes in diet. Even before the chemistry of these substances was unraveled, the civilized world was enchanted with the magic of vitamins. They brought hope that incurable diseases could be remedied by simple dietary additions. Today we understand what vitamins do and why they cure de? ciency diseases, but we still hold out hope for more miracles from these small molecules. And we might get a few. Scientists continue to discover important links between vitamins and the risk of developing illnesses such as heart disease, cancer, osteoporosis, and high blood pressure. What is being uncovered is far subtler than the miracle cures of the 19thcentury de? iency diseases, but people cling to the belief that taking more vitamins will cure what ails them. As a result of this â€Å"more is always better† attitude vitamin toxicities have become a concern. A toxic reaction can be as devastating as a de? ciency. Trying to get the right amount of each of the vitamins may sound analogous to walking a tightr ope between not enough and too much. In reality it is not that hard to get enough of most vitamins from a well-planned diet and most toxicities are not caused by foods but rather by excessive use of supplements. Vitamins provide many different functions in the body To date, 13 substances have been identi? ed as vitamins essential in the diet (Table 8. 1). They were named alphabetically in approximately the order in which they were identi? ed: A, B, C, D, and E. The B vitamins were ? rst thought to be one chemical substance but were later found to be many different substances, so the alphabetical name was broken down by numbers. Vitamins B6 and B12 are the only ones that are still commonly referred to by their numbers. Thiamin, ribo? avin, and niacin were originally referred to as vitamin B1, B2, and B3, respectively, but today they are not typically called by these names. Vitamins each have a unique role in the body. For instance, vitamin A is needed for vision, vitamin K is needed for blood clotting, and vitamin C is needed to synthesize connective tissue. Many body processes require the presence of more than one vitamin. For example the B vitamins thiamin, ribo? avin, niacin, biotin, and pantothenic acid are all needed to produce ATP from carbohydrate, fat, and protein. In some cases adequate amounts of one vitamin depend on the presence of another. For example, vitamin B12 is needed to provide the form of folate needed for cell division and vitamin C helps restore vitamin E to its active form. Vitamins Are Vital to Your Health 237 TABLE 8. 1 Where Does Each Vitamin Fit? Water-Soluble Vitamins B Vitamins †¢ Thiamin (B1) †¢ Ribo? avin (B2) †¢ Niacin (B3) †¢ Biotin †¢ Pantothenic acid †¢ Vitamin B6 †¢ Folate †¢ Vitamin B12 Vitamin C Fat-Soluble Vitamins Vitamin A Vitamin D Vitamin E Vitamin K Vitamins are found in almost everything you eat Almost all foods contain some vitamins (Figure 8. 1). Grain products are good sources of the B vitamins thiamin, niacin, ribo? avin, pantothenic acid, and vitamin B6. Meats, such as beef, pork, and chicken, and ? sh are good sources of all of the B vitamins. Milk provides ribo? avin and vitamins A and D; leafy greens, such as spinach and kale, provide folate, vitamin A, vitamin E, and vitamin K; citrus fruits like oranges and grapefruit provide vitamin C; and vegetable oils, such as corn and saf? ower oil, are high in vitamin E. FIGURE 8. 1 All the food groups contain choices that are good sources of vitamins. ( © Topic Photo Agency) (PhotoDisc, Inc. /Getty Images) Processing affects vitamin content The amount of a vitamin in a food depends on the amount naturally found in that food as well as how the food is cooked, stored, and processed. The vitamins naturally found in foods can be washed away during preparation, destroyed by cooking, or damaged by exposure to light or oxygen. Thus, processing steps such as canning vegetables, re? ning grains, and drying fruits can cause nutrient losses. However, other processing steps such as forti? cation and enrichment add nutrients to foods. Some nutrients are added to foods to prevent vitamin or mineral de? ciencies and promote health in the population (see Chapter 10). For example, milk is forti? ed with vitamin D to promote bone health, and grains are forti? ed with folic acid to reduce the incidence of birth defects. Some foods are also forti? ed with nutrients to help increase product sales. Dietary supplements can boost vitamin intake We also get vitamins in dietary supplements. Currently about half of adult Americans take some form of dietary supplement on a daily basis and 80% take them occasionally. 1 While supplements provide speci? c nutrients, they do not provide all the bene? ts of foods. A pill that meets vitamin needs does not provide the energy, protein, minerals, ? ber, or phytochemicals that would have been supplied by food sources of these vitamins (see Chapter 10). Not all of what you eat can be used by the body The vitamins that we consume in our diets are needed in the cells and ? uids of our body. In order to provide their essential functions, vitamins must get to the target tissues. The amount of a nutrient consumed that can be used by the body is referred to as its bioavailability. Bioavailability is affected by the composition of individual foods, the diet as a whole, and conditions in the body. For example, the thiamin in certain individual foods such as blueberries and red cabbage cannot be used by the body because these foods contain antithiamin factors that destroy the thiamin. An example of how L Forti? cation A term used generally to * describe the addition of nutrients to foods, such as the addition of vitamin D to milk. L Enrichment The addition of speci? c * nutrients to a food to restore those lost in processing to a level equal to or higher than originally present. L Dietary supplement A product * intended for ingestion in the diet that contains one or more of the following: vitamins, minerals, plant-derived substances, amino acids, or concentrates or extracts. L Bioavailability A general term that * refers to how well a nutrient can be absorbed and used by the body. 38 Chapter 8 The Vitamins Chewing helps break apart fiber and release vitamins Bile produced by the liver helps to absorb fat-soluble vitamins Digestion in the stomach releases vitamins from food Some niacin absorption Liver Stomach Digestive enzymes released by pancreas help to further release vitamins Fat-soluble vitamins absorbed from micelles along with dietary fat Pancreas Water-sol uble vitamins (thiamin, riboflavin, niacin, vitamin B6, biotin, pantothenic acid) absorbed by simple diffusion, facilitated diffusion, and active transport Vitamin C absorbed in later portion (ileum) of small intestine Small Intestine Vitamin B12 absorbed in later portion (ileum) of small intestine Large Intestine Absorption of small amounts of vitamin K, biotin, and pantothenic acid made by bacteria in the large intestine FIGURE 8. 2 An overview of vitamins in the digestive tract. diet composition affects vitamin bioavailability is dietary fat and the absorption of fatsoluble vitamins. Because fat-soluble vitamins are absorbed along with dietary fat, diets very low in fat reduce absorption (Figure 8. 2). Conditions in the body affect bioavailability in several ways. Some vitamins require speci? c molecules in order to be absorbed. If these aren’t available, the vitamin cannot be absorbed in suf? cient amounts. For example, vitamin B12 must be bound to a protein produced in the stomach before it can be absorbed in the intestine. If this protein is not available, adequate amounts of vitamin B12 cannot be absorbed. Other vitamins require transport molecules to travel in the blood to the tissues that need them. Vitamin A is stored in the liver, but it must be bound to a speci? transport protein to travel in the blood to other tissues; therefore, the amount delivered to the tissues depends on the availability of the transport protein. We need enough but not too much of each vitamin The right amounts and combinations of vitamins and other nutrients are essential to health. Despite our knowledge of what vitamins do and how much of each we need, we don’t all consume the right amounts. In developing countries, vitamin de? ciencies remain a major public health problem. In industrialized countries, a more varied food supply, along with forti? ation, has almost eliminated vitamin-de? ciency diseases in the majority of the population. Concern in these countries now focuses on meeting the needs of high-risk groups such as children and pregnant women, determining the effects of marginal de? ciencies such as the effect of low B vitamin intake on heart disease risk, and evaluating the risk of consuming large amounts. The RDAs and AIs of the Dietary Reference Intakes (DRI) recommend amounts that provide enough of Vitamins Are Vital to Your Health 239 each of the vitamins to prevent a de? ciency and promote health (see Chapter 2). Because more is not always better when it comes to nutrient intake, the DRIs have also established Tolerable Upper Intake Levels (ULs) as a guide to amounts that are high enough to pose a risk of toxicity (see inside cover). Some vitamins are soluble in water and others are soluble in fat We group vitamins based on their solubility in water or fat, a characteristic that affects how they are absorbed, transported, excreted, and stored in the body. The watersoluble vitamins include the B vitamins and vitamin C. The fat-soluble vitamins include vitamins A, D, E, and K (see Table 8. 1) With he exception of vitamin B12, the water-soluble vitamins are easily excreted from the body in the urine. Because they are not stored to any great extent, supplies of most water-soluble vitamins are rapidly depleted and they must be consumed regularly in the diet. Nevertheless, it takes more than a few days to develop de? ciency symptoms, even when these vitamins are completely eliminated from the diet. Fatsoluble vitamins, on the other hand, are stored in the liver and fatty tissues and cannot be excreted in the urine. In general, because they are stored to a larger extent, it takes longer to develop a de? iency of fat-soluble vitamins when they are no longer provided by the diet. In this chapter the water-soluble vitamins are presented ? rst because many play an important role in the reactions that produce energy from carbohydrate, fat, and protein that have been addressed in Chapters 4 through 7 (Table 8. 2). L Water-soluble vitamins Vitamins that * dissolve in water. L Fat-soluble vitamins Vitamins that * dissolve in fat. TABLE 8. 2 A Quick Guide to the Water-Soluble Vitamins Food Sources Pork, whole and enriched grains, seeds, nuts, legumes Recommended Intake for Adults 1. –1. 2 mg/day Major Functions Coenzyme in glucose metabolism, needed for neurotransmitter synthesis and normal nerve function Coenzyme needed in energy metabolism De? ciency Symptoms Berberi: weakness , apathy, irritability, nerve tingling, poor coordination, paralysis, heart changes In? ammation of mouth and tongue, cracks at corners of the mouth Pellagra: diarrhea, dermatitis on areas exposed to sun, dementia Groups at Risk of De? ciency Alcoholics, those living in poverty Toxicity and UL None reported. No UL Vitamin Thiamin (vitamin B1, thiamin mononitrate) Ribo? vin (vitamin B2) Dairy products, 1. 1–1. 3 mg/day whole and enriched grains, leafy green vegetables, meats Beef, chicken, ? sh, peanuts, legumes, whole and enriched grains. Can be made from tryptophan 14–16 mg NE/day None None reported. No UL Niacin (nicotinamide, nicotinic acid, vitamin B3) Coenzyme needed in energy metabolism and lipid synthesis and breakdown Those consuming a limited diet based on corn, alcoholics Flushing, nausea, rash, tingling extremities. UL is 35 mg from forti? ed foods and supplements (Continued) 240 Chapter 8 The Vitamins TABLE 8. 2 (Continued ) Food Sources Liver, egg yolks, synthesized in the gut Recommended Intake for Adults 30 g/day Major Functions De? ciency Symptoms Groups at Risk of De? ciency Those consuming large amounts of raw egg whites, alcoholics None Toxicity and UL None reported. No UL Vitamin Biotin Coenzyme in Dermatitis, glucose production nausea, and lipid synthesis depression, hallucinations Pantothenic acid (calcium pantothenate) Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) Meat, legumes, whole grains, widespread in foods Meat, ? sh, poultry, legumes, whole grains, nuts and seeds Leafy green vegetables, legumes, seeds, enriched grains 5 mg/day Coenzyme in Fatigue, rash energy metabolism and lipid synthesis and breakdown Coenzyme in protein metabolism, neurotransmitter and hemoglobin synthesis Coenzyme in DNA synthesis and amino acid metabolism Headache, numbness, tingling, convulsions, nausea, poor growth, anemia Macrocytic anemia, in? ammation of tongue, diarrhea, poor growth, neural tube defects Pernicious anemia, macrocytic anemia, nerve damage Scurvy: poor wound healing, bleeding gums, loose teeth, bone fragility, joint pain, pinpoint hemorrhages Liver dysfunction None reported. No UL Numbness, nerve damage. UL is 100 mg 1. 3–1. 7 mg/day Women, alcoholics Folate (folic acid, folacin, pteroyglutamic acid) 400 g DFE/day Pregnant women, alcoholics Masks B12 de? ciency. UL is 1000 g from forti? ed food and supplements None reported. No UL Animal products 2. 4 g/day Vitamin B12 (cobalamin, cyanocobalamin) Coenzyme in folate metabolism, nerve function Vegans, women, those with stomach or intestinal disease Alcoholics, elderly men Vitamin C (ascorbic acid, ascorbate) Citrus fruit, broccoli, strawberries, greens, peppers 75–90 mg/day Collagen (connective tissue) synthesis; hormone and neurotransmitter synthesis, antioxidant Synthesis of cell membranes and neurotransmitters GI distress, diarrhea. UL is 2000 mg Choline* Egg yolks, organ meats, leafy greens, nuts, body synthesis 425–550 mg/day None Sweating low blood pressure, liver damage. UL is 3500 mg UL, Tolerable Upper Intake Level; NE, niacin equivalent; DFE, dietary folate equivalent. *Choline is technically not a vitamin but recommendations have been made for its intake. Many B Vitamins Are Essential for Energy Production 241 Many B Vitamins Are Essential for Energy Production For many people the term vitamin is synonymous with energy. But vitamins do not actually contain any energy at all. We get energy from the carbohydrate, fat, and protein in our diet, but we can’t use the energy contained in these nutrients without the help of vitamins. The B vitamins thiamin, ribo? avin, niacin, pantothenic acid, and biotin are directly involved in converting the energy in carbohydrate, fat, and protein into ATP—the form of energy that is used to run the body (Figure 8. 3). Each of these vitamins acts as a coenzyme in one or more of the chemical reactions necessary to generate usable energy from these nutrients (Figure 8. 4). Thiamin: important for nerve function Thiamin is needed for nerve cells to obtain energy and to synthesize an important neurotransmitter. A de? ciency of thiamin causes beriberi, a condition that has been known for over 1000 years in East Asian countries. In Sri Lanka, the word beriberi literally means â€Å"I cannot†; this phrase refers to the extreme weakness that is the earliest symptom of the condition. Beriberi came to the attention of Western medicine in colonial Asia in the 19th century. It became such a problem that the Dutch East India Company sent a team of scientists to ? nd its cause. What they were expecting to ? d was a germ like those that caused cholera and rabies. What they found for a long time was nothing. For over 10 years, a young physician named Christian Eijkman worked C C C C C C Although people often take B vitamins to get more energy these vitamins do not actually provide energy. They are however necessary for the body to produce energy from other nutrients. L Coenzymes Small nonprotein o rganic * molecules that act as carriers of electrons or atoms in metabolic reactions and are necessary for the proper functioning of many enzymes. L Beriberi The disease resulting from a * de? iency of thiamin. O C C O C C C C C OH C C Glucose Fatty acid Amino acids Niacin Biotin Niacin Riboflavin Biotin Pantothenic acid Niacin Riboflavin Biotin Pantothenic acid O2 Thiamin Riboflavin Niacin Pantothenic acid C C Thiamin Riboflavin Pantothenic acid C C C Niacin Riboflavin H2O CO2 ATP FIGURE 8. 3 Thiamin, ribo? avin, niacin, biotin, and pantothenic acid are needed in the reactions that produce energy from carbohydrate, fat, and protein. If one of these is missing, energy production is disrupted. 242 Chapter 8 The Vitamins Coenzyme Incomplete enzyme Active enzyme A B A B Enzyme reaction FIGURE 8. 4 The B vitamins serve as coenzymes. This ? gure shows that the coenzyme must bind to form an active enzyme. The enzyme in this example can then join A and B to form a new molecule, shown here as AB. AB to ? nd the cause of beriberi. His success came as a twist of fate. He ran out of food for his experimental chickens and instead of the usual brown rice, he fed them white rice. Shortly thereafter, the chickens came down with beriberi-like symptoms. When he fed them brown rice again, they got well. What did this mean? To Eijkman it provided evidence that the cause of beriberi was not a poison or a microorganism, but rather something missing from the chicken feed. The incidence of beriberi in East Asia increased dramatically the 1800s due to the rising popularity of polished rice. Polished or white rice is produced by polishing off the bran layer of brown rice creating a more uniform product. However, polishing off the bran also removes the vitamin-rich portion of the grain (Figure 8. 5). Therefore, in populations where white rice was the staple of the diet, beriberi, became a common health problem. FIGURE 8. 5 Unenriched white rice is a poor source of thiamin. (Charles D. Winters) L Wernicke-Korsakoff syndrome A form * of thiamin de? ciency associated with alcohol abuse that is characterized by mental confusion, disorientation, loss of memory, and a staggering gait. Thiamin is needed to produce energy from glucose The reason thiamin is needed for nerve cells to obtain energy is because it is a coenzyme for some of the important energy-yielding reactions in the body. One of these is essential for the production of energy from glucose, the energy source for nerve cells. In addition to its role in energy production it is needed for neurotransmitter synthesis and is also essential for the metabolism of other sugars and certain amino acids, and for the synthesis of ribose, a sugar that is part of the structure of RNA (ribonucleic acid). Thiamin de? ciency affects the nervous and cardiovascular systems. Without thiamin, glucose, which is the primary fuel for the brain and nerve cells, cannot be used normally and nerve impulses cannot be transmitted normally. This leads to weakness and depression, which are the ? st symptoms of beriberi; other neurological symptoms include poor coordination, tingling sensations, and paralysis. The reason de? ciency affects the cardiovascular system is not well understood, but symptoms include rapid heartbeat and enlargement of the heart. Overt beriberi is rare in North America today, but a form of thiamin de? ciency called Wernicke-Korsakoff syndrome does occur in alcoholics. People with this condition experience mental confusion, psychosis, memory disturbances, and eventually coma. They are particularly vulnerable because thiamin absorption is decreased due to the effect of alcohol on the gastrointestinal tract. In addition, thiamin intake is low because alcohol contributes calories to the alcoholic’s diet but brings with it almost no nutrients. Many B Vitamins Are Essential for Energy Production RDA Sunflower seeds (1/4 c) Walnuts (1/4 c) Peanuts (1/4 c) Lentils (1 c) Pork (3 oz) Beef (3 oz) Trout (3 oz) Chicken (3 oz) 2% Milk (1 c) Cheddar cheese (1. 5 oz) Orange juice (1 c) Kiwi (2 med) Apple (1 med) Corn (1/2 c) Asparagus (1/2 c) Spinach, raw (1 c) Oatmeal (1 c) Spaghetti (1 c) Brown rice (1 c) White bread (2 sl) Whole-wheat bread (2 sl) 0 0. 2 0. 4 0. 6 0. 8 Thiamin (mg) 1. 0 1. 2 243 FIGURE 8. 6 Thiamin content of selections from each group of the Food Guide Pyramid. The dashed line represents the RDA for adult men. Pork is a better source of thiamin than other meats. (Randy Mayor/Foodpix/PictureArts Corp. ) The recommended intake for thiamin can be met by eating a varied diet You can meet your needs for thiamin by snacking on sun? ower seeds and having a serving of roast pork for dinner. These foods are exceptionally good sources of thiamin. Together 3 ounces of pork and a quarter cup of sun? ower seeds provide 1. 5 mg of thiamin, well above the RDA, which is 1. mg per day for adult men age 19 and older and 1. 1 mg per day for adult women 19 and older. 2 But even a diet that doesn’t include these foods can meet your thiamin needs as long as you make nutritious choices such as those recommended by the Food Guide Pyramid (Figure 8. 6). Legumes, nuts, and seeds are good sources. Grains are also good sources; thiamin is found in the bran of whole grains and i t is added to enriched re? ned grains. A large proportion of the thiamin consumed in the United States comes from enriched grains used in foods such as baked goods. Some breakfast cereals are forti? d with so much additional thiamin that a single bowlful contains more than the RDA. Although it is easy to meet thiamin needs some of the thiamin in foods may be destroyed during cooking or storage because it is sensitive to heat, oxygen, and low-acid conditions. Thiamin availability is also affected by the presence of antithiamin factors that destroy the vitamin. There are enzymes in raw shell? sh and freshwater ? sh that degrade thiamin during food storage and preparation and during passage through the gastrointestinal tract. These enzymes are destroyed by cooking so they are only a concern in foods consumed raw. Other antithiamin factors that are not inactivated by cooking are found in tea, coffee, betel nuts, blueberries, and red cabbage. Habitual consumption of foods containing antithiamin factors increases the risk of thiamin de? ciency. 2 Despite the fact that intakes of thiamin above the RDA have not been shown to be bene? cial, many supplements contain up to 50 mg of thiamin and promise that they will provide â€Å"more energy. † Although thiamin is needed to produce energy, unless it is de? cient, increasing thiamin intake does not increase the ability to produce energy. There is no UL for thiamin since no toxicity has been reported when excess is consumed from either food or supplements. 2 Enriched grains have thiamin as well as ribo? avin, niacin, and iron added to them (see Chapter 4). * Remember 244 Chapter 8 The Vitamins Ribo? avin: a bright yellow vitamin Ribo? avin is a water-soluble vitamin that provides a visible indicator when you consume too much of it. Excess is excreted in your urine—turning it a bright ? uorescent yellow. The color may surprise you but it is harmless. No adverse effects have been reported from high doses of ribo? vin from foods or supplements. FIGURE 8. 7 Milk is packaged in opaque or cloudy containers to protect its ribo? avin from destruction by light. (Charles D. Winters) Milk is the best source of ribo? avin in the North American diet Ever wonder why milk comes in opaque cardboard or cloudy plastic containers? The reason is that it is one of the best sources of ribo? avin in our diet and ribo? avin is destroy ed by light. If your milk was in a clear glass bottle and sat in a lighted grocery store display case for several days much of the ribo? avin would be destroyed. The most ribo? vin-friendly milk containers are opaque so the ribo? avin is fully protected from light (Figure 8. 7). Other major dietary sources of ribo? avin include other dairy products, liver, red meat, poultry, ? sh, whole grains, and enriched breads and cereals. Vegetable sources include asparagus, broccoli, mushrooms, and leafy green vegetables such as spinach. The RDA for ribo? avin for adult men age 19 and older is 1. 3 mg per day and for adult women 19 and older, 1. 1 mg per day. 3 Two cups of milk provide about half the amount of ribo? avin recommended for a typical adult. If you do not include milk in your diet you can meet your ribo? avin needs by including two to three servings of meat and four to ? ve servings of enriched grain products and high-ribo? avin vegetables such as spinach (Figure 8. 8). Ribo? avin is needed to produce energy from carbohydrate, fat, and protein Ribo? avin has two active coenzyme forms that function in producing energy from carbohydrate, fat, and protein. Ribo? avin is also involved directly or indirectly in converting a number of other vitamins, including folate, niacin, vitamin B6, and vitamin K, into their active forms. When ribo? vin is de? cient, injuries heal poorly because new cells cannot grow to replace the damaged ones. Tissues that grow most rapidly, such as the skin and the lin- RDA Sunflower seeds (1/4 c) Walnuts (1/4 c) Peanuts (1/4 c) Lentils (1 c) Pork (3 oz) Beef (3 oz) Trout (3 oz) Chicken (3 oz) 2% Milk (1 c) Cheddar cheese (1. 5 oz) Orange juice (1 c) Kiwi (2 med) Apple (1 med) Corn (1/2 c) Asparagus (1 /2 c) Spinach, raw (1 c) FIGURE 8. 8 Ribo? avin content of selections from each group of the Food Guide Pyramid. The dashed line represents the RDA for adult men. Milk is an exceptionally good source of ribo? avin. Corbis Images) Oatmeal (1 c) Spaghetti (1 c) Brown rice (1 c) White bread (2 sl) Whole-wheat bread (2 sl) 0 0. 4 0. 8 Riboflavin (mg) 1. 2 Many B Vitamins Are Essential for Energy Production 245 ings of the eyes, mouth, and tongue, are the ? rst to be affected. This causes symptoms such as cracking of the lips and at the corners of the mouth; increased sensitivity to light; burning, tearing, and itching of the eyes; and ? aking of the skin around the nose, eyebrows, and earlobes. A de? ciency of ribo? avin rarely occurs alone; it usually occurs in conjunction with de? ciencies of other B vitamins. This is because the same foods provide many of the B vitamins. Because ribo? avin is needed to convert other vitamins into their active forms, some of the symptoms seen with ribo? avin de? ciency re? ect de? ciencies of these other nutrients. Niacin: de? ciency caused an epidemic of mental illness In the early 1900’s psychiatric hospitals in the southeastern United States were ? lled with patients with the niacin-de? ciency disease pellagra. At the time, no one knew what caused it but the prime suspects were toxins or microorganisms. The mystery of pellagra was ? nally unraveled by Dr. Joseph Goldberger, who was sent by the U. S. Public Health Service to investigate the pellagra epidemic. He observed that individuals in institutions such as hospitals, orphanages, and prisons suffered from pellagra, but the staff did not. If pellagra were an infectious disease, both populations would be equally affected. Dr. Goldberger proposed that pellagra was due to a de? ciency in the diet. To test his hypothesis, he added nutritious foods such as fresh meats, milk, and eggs to the diet of children in orphanages. The symptoms of pellagra disappeared, supporting his hypothesis that pellagra is due to a de? ciency of something in the diet. In another experiment he was able to induce pellagra in healthy prison inmates by feeding them an unhealthy diet. The missing dietary component was later identi? ed as the water-soluble B vitamin niacin. L Pellagra The disease resulting from a * de? ciency of niacin. A niacin de? ciency causes dermatitis, diarrhea, and dementia The need for niacin is so widespread in metabolism that a de? ciency causes major changes throughout the body. The early symptoms of pellagra include fatigue, decreased appetite, and indigestion. These are followed by symptoms that can be remembered as the three D’s: dermatitis, diarrhea, dementia. If left untreated, niacin de? ciency results in a fourth D—death. Niacin coenzymes function in glucose metabolism and in reactions that synthesize fatty acids and cholesterol (see Figure 8. 3). There are two forms of niacin: nicotinic acid and nicotinamide. Either form can be used by the body to make the active coenzyme forms. Niacin is found in meats, legumes, and grains Meat and ? sh are good sources of niacin (Figure 8. 9). Other sources include legumes, wheat bran, and peanuts. Niacin added to enriched grains provides much of the usable niacin in the North American diet. Niacin can also be synthesized in the body from the essential amino acid tryptophan. Tryptophan, however, is only used to make niacin if enough is available to ? rst meet the needs of protein synthesis. When the diet is low in tryptophan, it is not used to synthesize niacin. The reason pellagra was prevalent in the South in the early 1900’s is because the local diet among the poor consisted of corn meal, molasses, and fatback or salt pork— all poor sources of both niacin and protein. Corn is low in tryptophan and the niacin found naturally in corn is bound to other molecules and therefore not well absorbed. Molasses contains essentially no protein or niacin and salt pork is almost pure fat, so it does not contain enough protein to both meet protein needs and synthesize niacin. Although corn-based diets such as this one are historically associated with the appearance of niacin de? ciency it has not been a problem in Mexico and Central American countries. One reason may be because the treatment of corn with lime water, as is done during the making of tortillas, enhances the availability of niacin (Figure 8. 10). The diet in these regions also includes legumes, which provide both niacin and a source of tryptophan for the synthesis of niacin. In searching for the cause of pellagra, Dr. Goldberger and his coworkers ingested blood, nasal secretions, feces, and urine from patients with the disease—none of them developed pellagra. This helped to disprove the hypothesis that pellagra was an infectious disease. 246 Chapter 8 The Vitamins RDA Sunflower seeds (1/4 c) Walnuts (1/4 c) Peanuts (1/4 c) Lentils (1 c) Pork (3 oz) Beef (3 oz) Trout (3 oz) Chicken (3 oz) 2% Milk (1 c) Cheddar cheese (1. 5 oz) Orange juice (1 c) Kiwi (2 med) Apple (1 med) Corn (1/2 c) Asparagus (1/2 c) Spinach, raw (1 c) FIGURE 8. 9 Niacin content of selections from each group of the Food Guide Pyramid. The dashed line represents the RDA for adult men. Meat, legumes, and grains are good sources of the vitamin. (PhotoDisc, Inc. /Getty Images) Oatmeal (1 c) Spaghetti (1 c) Brown rice (1 c) White bread (2 sl) Whole-wheat bread (2 sl) 0 2 4 6 8 10 Niacin (mg) 12 14 16 L Niacin equivalents (NEs) The * measure used to express the amount of niacin present in food, including that which can be made from its precursor, tryptophan. One NE is equal to 1 mg of niacin or 60 mg of tryptophan. Today, as a result of the enrichment of grains, including corn meal, with niacin, thiamin, ribo? vin, and iron, pellagra is rare in the United States but it remains common in India and parts of China and Africa. Efforts to eradicate this de? ciency include the development of new varieties of corn that provide more available niacin and more tryptophan than traditional varieties. Because some of the requirement for niacin can be met by the synthesis of niacin from tryptophan, the RDA is expressed as niacin equi valents (NEs). One NE is equal to 1 mg of niacin or 60 mg of tryptophan, the amount needed to make 1 mg of niacin. 3 To estimate the niacin contributed by high-protein foods, protein is considered to be about 1% tryptophan. The RDA for adult men and women of all ages is 16 and 14 mg NE per day, respectively. A medium chicken breast and a cup of steamed asparagus provide this amount. FIGURE 8. 10 Tortillas, eaten in Mexico and other Latin American countries, provide niacin because the corn is treated with lime water, making the niacin available for absorption. (Jeff Greenberg/Photo Researchers) Many B Vitamins Are Essential for Energy Production 247 High-dose niacin supplements can be toxic There is no evidence of any adverse effects from consumption of niacin naturally occurring in foods, but supplements can be toxic. The adverse effects of high intakes of niacin include ? ushing of the skin, a tingling sensation in the hands and feet, a red skin rash, nausea, vomiting, diarrhea, high blood sugar levels, abnormalities in liver function, and blurred vision. The UL for adults is 35 mg, but high-dose supplements of one form of niacin (50 mg or greater) are used under medical supervision to treat elevated blood cholesterol (see Chapter 5). Another form is under investigation for its bene? ts in the prevention and treatment of diabetes. When vitamins are taken in large doses to treat diseases that are not due to vitamin de? iencies, they are really being used as drugs rather than vitamins. Biotin: eggs contain it but can block its use You probably know that you shouldn’t eat raw eggs because they can contain harmful bacteria, but did you know that eating raw eggs could cause a biotin de? ciency? Raw egg whites contain a protein called avidin that tightly binds biotin and prevents its absorption. Biotin was discovered when rats fed protein derived from raw egg whites developed a syndrome of hair loss, dermatitis, and neuromuscular dysfunction. Thoroughly cooking eggs kills bacteria and denatures avidin so that it cannot bind biotin (Figure 8. 1). FIGURE 8. 11 Raw eggs are often used to make high-protein health drinks. This is not recommended because raw eggs may contain bacteria that can make you sick, and egg whites contain a protein that makes biotin unavailable. (Charles D. Winters) Biotin is important in energy production and glucose synthesis Biotin is a coenzyme for a group of enzymes that add an acid group to molecules. It functions in energy production and in glucose synthesis. It is also important in the metabolism of fatty acids and amino acids (see Figure 8. 3). Although biotin de? iency is uncommon, it has been observed in those frequently consuming raw egg whites as well as people with malabsorption or protein-energy malnutrition, those receiving intravenous fe edings lacking biotin, and those taking certain anticonvulsant drugs for long periods. 3 Biotin de? ciency in humans causes nausea, thinning hair, loss of hair color, a red skin rash, depression, lethargy, hallucinations, and tingling of the extremities. Biotin is consumed in the diet and made by bacteria in the gut Good sources of biotin in the diet include cooked eggs, liver, yogurt, and nuts. Fruit and meat are poor sources. Biotin is also synthesized by bacteria in the gastrointestinal tract. Some of this is absorbed into the body and contributes to our biotin needs. An AI of 30 mg per day has been established for adults based on the amount of biotin found in a typical North American diet. High doses of biotin have not resulted in toxicity symptoms; there is no UL for biotin. Pantothenic acid: widely distributed in food and widely used in the body Pantothenic acid, which gets its name from the Greek word pantos (meaning â€Å"from everywhere†), is widely distributed in foods. It is particularly abundant in meat, eggs, whole grains, and legumes. It is found in lesser amounts in milk, vegetables, and fruits. In addition to being â€Å"from everywhere† in the diet, pantothenic acid seems to be needed everywhere in the body. It is part of a key coenzyme needed for the breakdown of carbohydrates, fatty acids, and amino acids as well as the modi? cation of proteins and the synthesis of neurotransmitters, steroid hormones, and hemoglobin. Pantothenic acid is also part of a coenzyme essential for the synthesis of cholesterol and fatty acids (see Figure 8. 3). The wide distribution of pantothenic acid in foods makes de? ciency rare in humans. It may occur as part of a multiple B vitamin de? iency resulting from malnutrition or chronic alcoholism. The AI is 5 mg per day for adults. Pantothenic acid is relatively nontoxic and there are not suf? cient data to establish a UL. 3 248 Chapter 8 The Vitamins Vitamin B6 Is Important in Protein Metabolism Vitamin B6 is one of only two B vitamins that we still know by its number. The ch emical name for vitamin B6 is pyridoxine but we rarely hear it called this. The important role of vitamin B6 in amino acid metabolism distinguishes it from the other B vitamins. Vitamin B6 is needed to synthesize and break down amino acids Vitamin B6 has three forms—pyridoxal, pyridoxine, and pyridoxamine. These can be converted into the active coenzyme form, pyridoxal phosphate, which is needed for the activity of more than 100 enzymes involved in the metabolism of carbohydrate, fat, and protein. It is particularly important in amino acid synthesis and breakdown; without vitamin B6 the non-essential amino acids cannot be made in the body (Figure 8. 12). Pyridoxal phosphate is needed to synthesize hemoglobin, the oxygen-carrying protein in red blood cells, and is important for the immune system because it is needed to form white blood cells. It is also needed for the conversion of tryptophan to niacin, the release of glucose from the carbohydrate storage molecule glycogen, the synthesis of certain neurotransmitters, and the synthesis of the lipids that are part of the myelin coating on nerves, which is essential for normal transmission of nerve signals. Vitamin B6 de? ciency causes numbness and tingling Vitamin B6 de? ciency causes neurological symptoms including numbness and tingling in the hands and feet as well as depression, headaches, confusion, and seizures. These symptoms may be related to the role of vitamin B6 in neurotransmitter synthesis and myelin formation. Anemia also occurs in vitamin B6 de? ciency, because without B6 hemoglobin cannot be synthesized normally. Other de? ciency symptoms such as poor growth, skin lesions, and decreased antibody formation may occur because of the central role vitamin B6 plays in protein and energy metabolism. Since vitamin B6 is needed for amino acid metabolism, the onset of a de? ciency can be hastened by a diet that is low in vitamin B6 but high in protein. H H2N C C O OH Amino acids NH2 C O OH B6 Energy production and glucose synthesis B6 B6 FIGURE 8. 12 Vitamin B6 is essential for many different types of reactions involving amino acids. It is needed to remove the acid group so neurotransmitters can be synthesized, to remove the amino group so what remains can be used to produce energy or synthesize glucose, and to transfer an amino group to make a new amino acid. Neurotransmitter synthesis NH2 Synthesis of nonessential amino acids Vitamin B6 Is Important in Protein Metabolism Folic acid from food and supplements 249 DNA synthesis Active folate Vitamin B12 Inactive folate Methionine High levels in the FIGURE 8. 13 blood increase cardiovascular The accumulation of homocysteine in the blood is associated with an disease risk Homocysteine Vitamin B6 increased risk of heart disease. Vitamins B6, B12, and folate, are needed to keep homocysteine levels in the normal range. Vitamin B6 is needed to break down homocysteine. Vitamin B12 and folate are needed to convert homocysteine to methionine. Vitamin B6 status is related to heart disease risk Vitamin B6 is needed to break down the amino acid homocysteine. If B6 levels are low, homocysteine can’t be broken down and levels rise. Even a mild elevation in blood homocysteine levels has been shown to be a risk factor for heart disease (Figure 8. 13). Two other B vitamins, folate and vitamin B12 are also involved in homocysteine metabolism. These are needed to convert homocysteine to the amino acid methionine. If they are unavailable, homocysteine levels will increase. A study that examined the effect of folate and vitamin B6 intake in women found that those with the highest levels in their diets had about half the risk of coronary heart disease as women wit h the lowest levels. 5 Both animal and plant foods are good sources of vitamin B6 Animal sources of vitamin B6 include chicken, ? sh, pork, and organ meats. Good plant sources include whole wheat products, brown rice, soybeans, sun? ower seeds, and some fruits and vegetables such as bananas, broccoli, and spinach (Figure 8. 14). Re? ned grains, like white rice and white bread, are not good sources of vitamin B6, because the vitamin is lost in re? ning whole grains but is not added back in enrichment. It is added to many forti? ed breakfast cereals; these make an important contribution to vitamin B6 intake. 6 It is destroyed by heat and light, so it can easily be lost in processing. The RDA for vitamin B6 is 1. 3 mg per day for both adult men and women 19 to 50 years of age. A 3-ounce (85-g) serving of chicken, ? sh, or pork, or half a baked potato, provides about one-fourth of the RDA for an average adult; a banana provides about one-third. Too much vitamin B6 is toxic For years people assumed that because water-soluble vitamins were excreted in the urine they could not cause toxic reactions. However, reports in the 1980’s of seve re nerve impairment in individuals taking 2 to 6 g of pyridoxine per day showed these assumptions to be false. 7 The reactions of some supplement users were so severe that they were unable to walk; symptoms improved when the pyridoxine supplements were stopped. The UL for adults is set at 100 mg per day from food and supplements. 3 Despite the potential for toxicity, high-dose supplements of vitamin B6 containing 100 mg per dose (5000% of the Daily Value) are available over the counter, making it easy to obtain a dose that exceeds the UL. These supplements are taken to reduce the symptoms of premenstrual syndrome (PMS), treat carpal tunnel syndrome, and strengthen immune function. Although studies have not found a relationship between carpal tunnel syndrome and vitamin B6 status, some studies report that low-dose supplements of vitamin B6 may reduce symptoms of PMS and improve immune function. Individuals with an inherited disease called homocysteinuria have extremely high levels of homocysteine in their blood and may have heart attacks and strokes by the age of 2. 250 Chapter 8 The Vitamins RDA Sunflower seeds (1/4 c) Walnuts (1/4 c) Peanuts (1/4 c) Lentils (1 c) Pork (3 oz) Beef (3 oz) Trout (3 oz) Chicken (3 oz) 2% Milk (1 c) Cheddar che ese (1. 5 oz) Orange juice (1 c) Kiwi (2 med) Apple (1 med) Corn (1/2 c) Asparagus (1/2 c) Spinach, raw (1 c) Oatmeal (1 c) Spaghetti (1 c) Brown rice (1 c) White bread (2 sl) Whole-wheat bread (2 sl) 0 0. 0. 8 Vitamin B6 (mg) 1. 2 FIGURE 8. 14 Vitamin B6 content of selections from each group of the Food Guide Pyramid. The dashed line represents the RDA for men and women up to 50 years of age. The best sources are meats, legumes, and whole grains. (David Bishop/Foodpix/PictureArts Corp. ) PMS causes mood swings, food cravings, bloating, tension, depression, headaches, acne, breast tenderness, anxiety, temper outbursts, and over 100 other symptoms. Because vitamin B6 is needed for the synthesis of the neurotransmitters serotonin and dopamine, insuf? ient vitamin B6 has been suggested to cause the anxiety, irritability, and depression associated with PMS by reducing levels of these neurotransmitters. Trials on the effect of vitamin B6 supplements on PMS have had con? icting resultsâ⠂¬â€ in some cases low-dose supplements appear to be effective in reducing symptoms. 9 Vitamin B6 supplements have been found to improve immune function in older adults, but the reason for the improvement is unclear. 10 Immune function can be impaired by a de? ciency of any nutrient that hinders cell growth and division. Therefore, one of the most common claims for vitamin supplements in general is that they improve immune function. Vitamin B6 is no exception. Since the elderly frequently have low intakes of vitamin B6, it is unclear whether the bene? cial effects of supplements are due to an improvement in vitamin B6 status or immune system stimulation. Folate and Vitamin B12 Are Needed for Cell Division Inside the nucleus of every cell is the DNA that holds the genetic code. Before a cell can divide it must make a copy of its DNA. The B vitamin folate is needed for the synthesis of DNA and vitamin B12 is needed to keep folate active. Therefore if either B12 or folate is missing, DNA cannot be copied and new cells cannot be made correctly. As a result of this interdependency, many of the same symptoms are seen when either vitamin B12 or folate are de? cient. Folate: important for rapidly dividing cells A number of different forms of folate are needed for the synthesis of DNA and the metabolism of some amino acids. Because folate is needed for cells to replicate, it is particularly important in tissues where cells are dividing rapidly such the bone marrow, where red blood cells are made, and the developing tissues of an unborn baby. Folate and Vitamin B12 Are Needed for Cell Division 251 folate adequate folate deficient Normal cell division Red blood cells Red blood cell precursor FIGURE 8. 15 Cells are unable to divide (megaloblast) Macrocyte Megaloblastic or macrocytic anemia occurs when developing blood cells are unable to divide, leaving large immature red blood cells (megaloblasts) and large mature red blood cells (macrocytes). Folate de? ciency results in anemia One of the most notable symptoms of folate de? ciency is anemia. Without folate, developing red blood cells cannot divide. Instead, they just grow bigger (Figure 8. 15). Fewer mature red cells are produced so the oxygen-carrying capacity of the blood is reduced. This condition is called megaloblastic or macrocytic anemia. Other symptoms of folate de? ciency include poor growth, problems in nerve development and function, diarrhea, and in? ammation of the tongue. Groups most at risk of a folate de? ciency include pregnant women and premature infants because of their rapid rate of cell division and growth; the elderly because of their limited intake of foods high in folate; alcoholics because alcohol inhibits folate absorption; and tobacco smokers because smoke inactivates folate in the cells lining the lungs. Folate intake is related to neural tube defects A low folate intake increases the risk of birth defects that affect the brain and spinal cord called neural tube defects (Figure 8. 16). The exact role of folate in neural tube development is not known, but it is necessary for a critical step called neural tube closure. Neural tube closure occurs ve ry early in pregnancy—only 28 days after conception—when most women may not yet even know they are pregnant. Therefore to reduce the risk of these defects, folate status must be adequate before a pregnancy begins and during the early critical days of pregnancy (see Chapter 12). However, folate is not the only factor contributing to neural tube defects. Not every pregnant woman with low folate levels gives birth to a child with a neural tube defect. Instead, these birth defects are probably due to a combination of factors that are aggravated by low folate levels. Folate status may affect heart disease and cancer risk Low folate intake may increase the risk of heart disease because of its relation to homocysteine levels (see Figure 8. 13). Low folate status may also increase the risk of developing cancer L Megaloblastic or macrocytic anemia * A condition in which there are abnormally large immature and mature red blood cells and a reduction in the total number of red blood cells and the oxygen-carrying capacity of the blood. L Neural tube defects Irregularities in * the formation of the portion of the embryo that develops into the brain and spinal cord. These occur early in development and result in brain and spinal cord abnormalities. Vertebrae Spinal cord Vertebrae Spinal cord FIGURE 8. 16 Early in pregnancy, the neural tube develops into the brain and spinal cord. If folate is inadequate during neural tube closure, neural tube defects such as spina bi? da, shown here, occur more frequently. In spina bi? da the bones that make up the back do not completely surround the spinal cord, allowing membranes, ? uid, and, in severe cases, the nerves of the spinal cord to bulge out where they are unprotected. Normal spine Spine with spina bifida 252 Chapter 8 The Vitamins For more information on folic acid and birth defects, go to the Spina Bifida Association of America at www. sbaa. org of the uterus, cervix, lungs, stomach, esophagus, and colon. Although folate de? iency does not cause cancer, it has been hypothesized that low folate intake enhances an underlying predisposition to cancer. The relation between folate and cancer is strongest for colon cancer. Alcohol consumption greatly increases the cancer risk associated with a low folate diet. 11 L Dietary folate equivalent (DFE) A unit * used to express the amount of folate available to the body that accounts for the higher bioavailability of folic acid in supplements and enriched foods compared to folate found naturally in foods. One DFE is equivalent to 1 g of folate naturally occurring in food, 0. 6 g of synthetic folic acid from forti? d food or supplements consumed with food, or 0. 5 g of synthetic folic acid consumed on an empty stomach. Vegetables, legumes, oranges, and grains are good sources of folate Asparagus, oranges, legumes, liver, and yeast are excellent food sources of folate. Fair sources include grains, corn, snap beans, mustard greens, and broccoli, as well as some nuts. Small amounts are found in meats, cheese, milk, fruits, and other vegetables (Figure 8. 17). Folic acid is added to enriched grain products, including enriched breads, ? ours, corn meal, pasta, grits, and rice. If you look at the label on a bag of enriched ? ur you will see that it is forti? ed with folic acid. Folic acid is a stable form of folate that rarely occurs naturally in food but is used in supplements and forti? ed foods; it is more easily absorbed than natural folate. In the 3-year period after the forti? cation of grain products with folic acid, the incidence of neural tube defects decreased by 25%. 12 Women of childbearing age need extra folate The RDA for folate is set at 400 g dietary folate equivalents (DFEs) per day for adult men and women. Expressing needs in DFEs allows one unit to be used for all the forms of folate; one DFE is equal to 1 g of food folate, 0. g of synthetic folic acid from forti? ed food or supplements consumed with food, or 0. 5 g of synthetic folic acid consumed on an empty stomach. Because supplementing folic acid early in pregnancy has been shown to reduce neural tube defects, a special recommendation is made for women capable of becoming pregnant; 400 g of synthetic folic acid from forti? ed foods and/or supplements is recommended in addition to the food folate consumed in RDA Sunflower seeds (1/4 c) Walnuts (1/4 c) Peanuts (1/4 c) Lentils (1 c) Pork (3 oz) Beef (3 oz) Trout (3 oz) Chicken (3 oz) 2% Milk (1 c) Cheddar cheese (1. oz) Orange juice (1 c) Kiwi (2 med) Apple (1 med) Corn (1/2 c) Asparagus (1/2 c) Spinach, raw (1 c) Oatmeal (1 c) Spaghetti (1 c) Brown rice (1 c) White bread (2 sl) Whole-wheat bread (2 sl) 0 100 200 Folate ( µg DFE) 300 400 FIGURE 8. 17 Folate content of selections from each group of the Food Guide Pyramid. The dashed line represents the RDA for adults. Legumes, forti? ed foods, and some fruits and vegetables are good sources. (George Semple) Folate and Vitamin B12 Are Needed for Cell Division 253 PIECE IT TOGETHER Is It Hard to Meet Folate Recommendations? Marcia would like to have a baby but before she tries to conceive, she wants to be sure she is in the best condition possible. She consults her physician who gives her a clean bill of health but suggests she make sure she is getting enough folate. women who are capable of becoming pregnant should consume 400 g of folic acid from forti? ed foods or supplements each day in addition to the folate found in a varied diet. Folic acid is added to enriched grains, so it can be found in any food that contains enriched grains; you can check the ingredient list to see if the food you have chosen contains added folic acid. The percent Daily Value includes both the natural folate and added folic acid. W HY IS FOLATE A CONCERN FOR WOMEN CAPABLE OF BECOMING PREGNANT ? M Research shows that consuming extra folic acid can reduce the risk of a type of birth defect called a neural tube defect that affects an unborn child’s brain or spinal cord. For the extra folic acid to be bene? cial, it must be consumed for at least a month before conception and continued for a month after. Since many pregnancies are not planned, it is recommended that all women of childbearing age consume 400 g of folic acid from forti? d foods or supplements. Marcia records her food intake for 1 day to determine her folate intake: Food Breakfast Oatmeal, regular Milk Banana Orange juice Coffee Lunch Hamburger Hamburger bun French fries Coke Apple Dinner Chicken Refried beans White rice Tortilla Salad Salad dressing Milk Cake Total Servings 1 cup 1 cup 1 medium 8 ounces 1 cup 1 1 20 pieces 12 ounces 1 medium 3 ounces 1/2 cup 1 cup 1 1 cup 1 Tbsp 1 cup 1 piece Total Folate ( g) 2 12 22 75 0 11 32 24 0 4 4 106 80 60 64 1 12 32 541 g FOLATE INTAKE MEET THE W HICH FOODS IN M ARCIA’ S DIET ARE HIGHEST IN FOLATE ? O F THESE , WHICH DO YOU THINK HAVE BEEN FORTIFIED WITH FOLIC ACID ? M Food Rice Orange juice Your answers: Amount 80 g 75 g Natural Forti? ed W HY IS THE OATMEAL LOW IN FOLATE BUT THE OTHER GRAIN PRODUCTS ARE GOOD FOLATE SOURCES ? M Oatmeal is a whole grain, so it has not been forti? ed with folic acid. The other grain products in her diet, such as the white rice, tortilla, and hamburger bun, are re? ned so they contain added folic acid. Even though Marcia is trying to increase her intake of the folic acid form of this vitamin she should not pass up whole grains—they are good sources of most B vitamins, minerals, and ? er. L IST SOME MODIFICATIONS M ARCIA COULD MAKE IN HER DIET TO PROVIDE THE RECOMMENDED AMOUNTS AND FORMS OF FOLATE ? M Your answer: W OULD YOU RECOMMEND M ARCIA TAKE A FOLATE SUPPLEMENT ? D OES M ARCIA’ S RDA? Your answer: M Yes. Marica consumes 541 g of folate, which is greater than the RDA of 400 g DFE, but her doctor told her that M 254 Chapter 8 The Vitamins Not everyone needs a folate supplement. If you are male or a female who is too young or too old to have a baby, the amount of folate you get from a healthy diet will meet your needs. Even women of childbearing age can get enough folic acid without a supplement if they eat enough folic acid forti? ed foods. a varied diet. The folic acid form is recommended because it is the form that has been shown to reduce birth defects. This recommendation is made for all women of childbearing age because folate is needed very early in a pregnancy—before most women are aware that they are pregnant. To get 400 g of folic acid, you would need to eat 4 to 6 servings of forti? ed grain products each day or take a supplement containing folic acid. Excess folate can mask anemia caused by vitamin B12 de? ciency Although extra folate is recommended for pregnant women, too much is a concern for some groups. There is no known folate toxicity, but a high intake may mask the early symptoms of vitamin B12 de? ciency, allowing it to go untreated so irreversible nerve damage can occur. The UL for adults is set at 1000 g per day of folate from supplements and/or forti? ed foods. This value was determined based on the progression of neurological symptoms seen in patients who are de? cient in vitamin B12 and taking folate supplements. L Pernicious anemia An anemia * resulting from vitamin B de? ciency that 12 Vitamin B12: absorption requires intrinsic factor If you lived in the early 1900’s and developed a condition called pernicious anemia, it was a death sentence. There was no cure. In the 1920’s researchers George Minot and William Murphy pursued their belief that pernicious anemia could be cured by something in the diet. Their experiments were able to restore good health to patients by feeding them about 4 to 8 ounces of slightly cooked liver at every meal. Today we know that liver contains high levels of vitamin B12. We also know that pernicious anemia is not actually caused by a lack of the vitamin in the diet, but rather an inability to absorb the vitamin. Vitamin B12 absorption requires a protein called intrinsic factor that is produced by cells in the stomach lining. With the help of stomach acid, intrinsic factor binds to vitamin B12 and this vitamin B12-intrinsic factor complex is then absorbed in the small intestine. When very large amounts of the vitamin are consumed, some can be absorbed without intrinsic factor. This is why Minot and Murphy were able to cure pernicious anemia with extremely high dietary doses of the vitamin. Today, pernicious anemia is treated with injections of vitamin B12 rather than plates full of liver. occurs due to a lack of a protein called intrinsic factor needed to absorb dietary vitamin B12. L Intrinsic factor A protein produced * in the stomach that is needed for the absorption of adequate amounts of vitamin B12. L Cobalamin The chemical term for * vitamin B . 12 Vitamin B12 is needed for nerve function Vitamin B12, also known as cobalamin, is necessary for the maintenance of myelin, which is the coating that insulates nerves and is essential for nerve transmission. Vitamin B12 is also needed for the production of energy from certain fatty acids and to convert homocysteine to methionine (see Figure 8. 13). This reaction also converts folate from an inactive form to a form that functions in DNA synthesis. Because of the need for vitamin B12 in folate metabolism, a de? ciency can cause a secondary folate de? ciency and, consequently, macrocytic anemia. Symptoms of vitamin B12 de? ciency include an increase in blood homocysteine levels and anemia that is indistinguishable from that seen in folate de? ciency. Other symptoms include numbness and tingling, bnormalities in gait, memory loss, and disorientation due to degeneration of the myelin that coats the nerves, spinal cord, and brain. If not treated, this eventually causes paralysis and death. Consuming extra folate can mask a vitamin B12 de? ciency When the diet is de? cient in vitamin B12, consuming extra folate can mask the vitamin B12 de? ciency by preventing the appearance of anemia. If the d e? ciency is not treated, the other symptoms of B12 de? ciency, such as nerve damage, progress and can be irreversible. This connection between folate and vitamin B12 has raised concerns that our folate-forti? d food supply may allow B12 de? ciencies to go unnoticed. So far, this

Analysis of Peter Pan Essay

In this study, we are going to talk about two histories of Children’s Literature, histories that are part of the history of this literature. The tales we are going to talk about have marked and for sure will mark the the childhood of many children in the world. This tales are â€Å"Peter Pan†, by James Matthew Barrie (1860–1937) who was a Scottish author and dramatist; and â€Å"The Wonderful Wizard of Oz† by Lyman Frank Baum (1856-1919), American children’s literature author, playwright and journalist. We are going to talk about their authors, about the time when this books were published and then we are going to analyze in depth the tales, talking about their settings, their characterisation, their narrative progression, their language and their plot. We are going to compare the book with their respective film and finally, we are going to compare â€Å"Peter Pan† with â€Å"The Wonderful Wizard of Oz† stories. 2. MAKING OFF: 1. 19th December: We went to Vallecas’ library. Here we showed us the individual information and we thought about the essay’s structure . We looked for more information about the stories, author, time†¦ Finally, we made the introduction of the work. We took books to take home to complete the individual information. 2. 10th January: We went to Vallecas? library. We had done our individual part and we had seen the two movies. We made together the individual most important parts (setting, narrative, progression, plot †¦) and the comparison between Peter Pan and the Wizard of Oz: Similarities and differences. Finally, we made the conclusion of the work. 3. 14th January: We went to the university library. We completed the bibliography on work and finished the index and the title page. 3. PART A – PETER PAN: AUTHOR: JAMES MATTHEW BARRIE James Matthew Barrie, (9 May 1860 – 19 June 1937) was a Scottish author and dramatist, best remembered today as the creator of Peter Pan. The child of a family of small-town weavers, he was educated in Scotland. He moved to London, where he developed a career as a novelist and playwright. There he met the Llewelyn Davies boys who inspired him in writing about a baby boy who has magical adventures in Kensington Gardens (included in The Little White Bird), then to write Peter Pan, or The Boy Who Wouldn’t Grow Up, a â€Å"fairy play† about this ageless boy and an ordinary girl named Wendy who have adventures in the fantasy setting of Neverland. Barrie was born in Kirriemuir, Angus, to a conservative Calvinist family. Barrie was the ninth child of ten (two of whom died before he was born), all of whom were schooled in at least the three Rs, in preparation for possible professional careers. Barrie wished to pursue a career as an author, but was dissuaded by his family He was to attend a university, but would study literature. He enrolled at the University of Edinburgh, where he wrote drama reviews for Edinburgh Evening Courant. He was extremely introverted, and was shy about the fact he was in college and only approximately five feet. He would go on to graduate with his M. A. on April 21, 1882. Meanwhile, Barrie’s attention turned increasingly to works for the theatre. The production of Barrie’s play at Toole’s Theatre in London was seen by William Archer, the translator of Ibsen’s works into English, who enjoyed the humour of the play and recommended it to others. Barrie travelled in high literary circles, and in addition to his professional collaborators, he had many famous friends. In 1896, his agent, Addison Bright persuaded him to meet with Broadway producer Charles Frohman. Frohman would become not only his financial backer, but a close friend as well. Frohman, who was responsible for producing the debut of Peter Pan in both England and the U. S. , as well as other productions of Barrie’s plays, famously declined a lifeboat seat when the RMS Lusitania was sunk by a German U-boat in the North Atlantic. Actress Rita Jolivet, who stood with Frohman, George Vernon, and Captain Alick Scott at the end, survived the sinking and recalled Frohman paraphrasing Peter Pan: ‘Why fear death? It is the most beautiful adventure that life gives us. Barrie argues that, before birth, all babies are birds, hence the image of Peter was born, a boy, when I was a baby, flew out the window of his room while his mother slept, because he had not lost faith that could fly. Believing be direct bird flew back to Kensington Gardens, where the serpentine lake within which lies the island of birds, also called â€Å"Neverland. † Peter Pan quickly overshadowed his previous work and although he continued to write successfully, it became his best-known work, credited with popularizing the name Wendy, which was very uncommon previously. Barrie unofficially adopted the Davies boys following the deaths of their parents. Before his death, he gave the rights to the Peter Pan works to Great Ormond Street Hospital, which continues to benefit from them. The first appearance of Peter Pan came in The Little White Bird, which was serialised in the United States, then published in a single volume in the UK in 1901. TIME: Although James Barrie was born in Scotland, he moved to London, where he developed a career as a novelist and playwright. In England, the queen Victoria had the longest reign with 64 years of government in the history of the British monarches, and the cultural, political, economic, industrial and scientific changes that happened during his reign were notable. When Victory ascended to the throne, England was essentially agrarian and rural; to his death, the country was highly industrialized. Between 1860 and 1870 the industrial revolution happens. The children must go to the school, but families need money, some children don? t go to school. For this one installs a Foster? s Law (1870): Obligatory education. Children to be educated at school. The literature was a very popular way of amusing itself in the Victorian Epoch and big writers arose. In children? s literature, the writers write for girls and for boys. Normally, woman writer write for girls. The type of book for girls is a domestic history: In house, with a family†¦ The type of book for boys is an adventure books. These topics were faraway places. The girls read adventure? s books hidden. In 1854 Charles Dickens publishes Oliver Twist. This book is a very famous because is a real boy the center of novel. This is a big innovation.

How Close to the ACT Should You Take a Practice Test

How Close to the ACT Should You Take a Practice Test SAT / ACT Prep Online Guides and Tips It’s extremely important to take full-length practice tests under realistic conditions when studying for the ACT. However, you need to make sure you’re getting the full benefit by spacing out the practice tests correctly. In this article, we'll discuss both the earliest and the latest you should consider taking full ACT practice tests. feature image credit: Smell!/used under CC BY 2.0/Cropped from original How Early Should You Take A Practice Test? There really isn’t any harm that can come out of taking a practice test long before the ACT as long as you’re planning on taking additional practice tests or studying more afterwards. In fact, taking a practice test at the very beginning of your studying is a good idea because it’ll give you an idea of what your current score would be if you took the ACT and what your weak spots are. Ideally, you’ll also take other practice tests over the course of your studying to assess your progress and determine if your studying is making a difference. If you’re only planning on taking one practice test before the real test, just to familiarize yourself with the format and instructions, then the earliest we recommend taking it is seven to eight days before your test; any earlier and you’ll start to forget things, cancelling out any value taking the practice test might have had for you. Again, this seven to eight day recommendation is assuming you’re only taking one practice test without any further studying; if you are planning on studying after taking your first practice test and taking more practice tests, then the next section of this article is more relevant for you. How Late Can You Take an ACT Practice Test? While taking realistic practice tests is an important part of ACT preparation, you don’t want to take a practice test too close to the test or it might have a bad effect on your morale (and, consequently, on your test score). If you do well on the practice test, it might artificially boost your self-confidence and cause you to make careless errors on the real test if you think you can just coast through. On the other hand, if you do poorly, it will just make you more stressed and anxious without giving you time to address those anxieties through studying, which in turn might cause you to second guess yourself and run out off time on the real test. 020/Used under CC BY 2.0/Cropped from original. Don't let this be you on test day! The latest that you take a practice test, therefore, should be the amount of time before the test that still allows you time to review your wrong answers and do some practice drills of questions you struggle with. When exactly this is will vary from student to student, but in general, we recommend taking your last practice test no fewer than two to three days before your scheduled test date. That means that if you’re taking a test on Saturday, the last full-length realistic practice test you take should be on Wednesday or Thursday of that week. It's important to keep in mind, however, that taking a full-length practice test with realistic timing is difficult on a schoolnight; plus, you don’t get the benefits of taking the test in the morning (and getting a realistic idea of what it’ll feel like to take the test early in the day). The Saturday or Sunday before the test, then, is the last chance you have to take a fully realistic practice test. Monday-Thursday before the test, you can try taking a full test or taking it section by section with a few sections grouped together, but be wary of unrealistic conditions because you're taking it in the evening and not all at once. An hour or so of practice is helpful the day before the test, as is(for non-anxious test-takers) doing a couple of practice questions before the test. What’s Next? Now that you know when to take ACT practice tests, where can you find them? Try our massive collection of online ACT practice tests, or just go straight to our collection of free printable ACT Practice Test PDFs. Looking to invest in a book for ACT prep? Read through our rundown of the best ACT prep books here. Want to complement your collection of ACT practice tests with some sample ACT questions? We have a list of great alternative sources of ACT prep material. Want to improve your ACT score by 4 points? Check out our best-in-class online ACT prep program. We guarantee your money back if you don't improve your ACT score by 4 points or more. Our program is entirely online, and it customizes your prep program to your strengths and weaknesses. We also have expert instructors who can grade every one of your practice ACT essays, giving feedback on how to improve your score. Check out our 5-day free trial:

Do You Mark Books Get Even More Arguments To Do It!

Do You Mark Books Get Even More Arguments To Do It! Tips on Marking a Book To mark or not to mark? Some people consider marking books disrespectful, while others think that it is an important part of the reading process.   There are those, who consider people marking their books untidy ones and they do everything they can to keep their own books clean. However, if you didn’t borrow a book from your fellows or in a library, there is absolutely nothing wrong in making notes on the pages of a book that you own. If you read the book for pleasure, there is no need to make notes, and in most of the cases, you will forget the plot right after the book is finished. However, if you want to get new information and knowledge, it is necessary not only to listen to the authors but to communicate with them. Making notes shows that you are interested in the book and that you are involved in the process. Marking a book may include making notes about words and phrases, rhetorical questions, complex terms, ideas or even elements you disagree with. Our article was created to guide you through the active reading process, to explain the importance of a marked book and the ways to do it efficiently. Necessity of Marking Books If you have already forgiven yourself for making notes on the book’s pages, you may notice that many reasons will help you benefit from the process.   Below we have gathered only some of the most important reasons why everyone should make notes on the pages and free spaces of a book. It Makes Second Reading Simpler If you are going to a certain city for the second time, it would be much easier to know where to go and what places to see, right? On your first trip, you can make notes on the places you liked or disliked: a cafà © with delicious local cuisine, a cozy park near the railway station or a bar with live music. Bookmarking is quite similar because it simplifies the process of second reading if you need it. You have already made a few points during the first reading: highlighted difficult words or phrases marked a new concept and wrote down its definition on a margin.That is why when the time comes to read the book once again, you will save your time and nerves looking for a complex word or term in a dictionary. Interacting with the Author Many people don’t like reading, because they find it boring as if they are listening to a college lecture. That is why marking a book helps to communicate with the writer, and you get involved in the discussion, reacting to the points you agree or disagree with. If you find a weird or controversial issue, you may be willing to conduct your own research and to find out more about the issue. Of course, this may be time-consuming and difficult at first, but if you practice regularly, it will become simpler with time. You Learn More Effectively Reading is one of the most efficient ways of learning new information. While it is a receptive skill, writing is a productive one, and a combination of both is a great way to turn passive reading into active learning. When you make notes, it is simpler to learn. Instead of just consuming the information you share it, diving deeper into the subject. It results in higher productivity, better results of remembering information and discovering new issues. You Learn How to Write It may not be obvious at first but marking a book helps to improve writing skills. When you are reading a book, you will surely find unfamiliar words, idioms, and concepts.   This helps to broaden your vocabulary and to notice how various writing instruments and tools are used throughout the text. With time you will find it much simpler to render your ideas, and the number of unknown words will be much lower! An Annotated Book Will Become a Great Gift Making notes is quite a personal thing, and most of the people don’t want to share it with others. However, if you are planning to hand your marked book to a relative or friend, you can be sure that it will become a unique and valuable present. You have spent lots of your time to make notes, mark terms and definitions and to put your thoughts on paper. If you are willing to give out your ideas to others, it will surely be appreciated. It is a result of your hard work and devotion, and it will make the recipient feel important and valuable. Tools for Marking a Book When you annotate a book, you need to understand what instruments will be efficient to achieve your initial goal. Here are the tips that will help you to choose the most suitable tools: If you decide to use a highlighter, make sure that the color allows reading the highlighted sentences without any difficulties. Light colors are the best ones. For example, yellow or orange. In addition, try to stick only to a few colors, because having a rainbow on a page will only distract you from the initial goal; If you prefer using a pen, make sure that it is of a dark color to make reading notes simpler; In case you don’t want to write on pages and prefer keeping the book clean, you can choose sticky notes. They are a great alternative to pens and highlighters, although it is more difficult and time-consuming to use them; If you are reading an electronic version (in an ePub, PDF or other formats), there is usually a bookmark option in the main menu, which allows making notes. It is a great alternative to regular notes and saves lots of time because you can easily navigate between pages and find a necessary bookmark simply by making a few clicks. It is very likely that you already have your own marking habits and style. However, there is always a place for improving them. You should pay attention to the following tips that may greatly improve your marking and annotating experience. Say No to Distractions If you decided to mark your book, you need to understand that it is not a regular reading and you will need to devote all of your attention to the process.   Make sure you read in a calm and quiet atmosphere without any distractions. If you don’t have your own room, choose a library or inform your roommates that you will be studying and will need some time alone. Don’t Be in a Hurry You may be used to reading a book on high speed but annotating is difficult and will take lots of your time. That is why you need to be involved in the process, making pauses and rereading paragraphs if necessary. There is no need to be in a hurry because your goal is to get as much knowledge as possible and not just to finish the book as soon as possible. If you want to master annotating, you need to do your job well. Always Highlight and Underline Words and Phrases That Are Important To begin with, you can highlight words or phrases that you find important. Use a highlighter or a pen to mark elements, which render the main ideas of the author. Even if you are not familiar with the words or structures, you need to highlight them and then conduct research to make everything clearer. However, you need to highlight only a few key words and sentences, because otherwise your pages will look too complex and clumsy, and you will find it difficult to use those notes later. Experiment With Shapes for Keywords If a certain word appears several times on a page, most likely it is one of the key points that the author is willing to render. Just be creative and use the shapes and colors you like. For example, blue rectangles or yellow circles. If the author is willing to attract your attention by a certain term, why don’t you highlight it? In case such brief marks are not enough, you can number them and then make notes on the margins to develop your thought on the issue. Use Punctuation Marks Luckily, there is a huge variety of marks to choose from. If you write a question mark after a sentence, it means that you didn’t get the point and want to clarify it. If you place an exclamation mark, it means that you are surprised to find out an important and previously unknown fact. Asterisk means that you can’t agree with the statement. It is possible to invent marks on your own, assigning them with a certain meaning. Moreover, it is allowed to use smiley faces and any symbols you want! It is your book, your marks, and your rules. Put Key Sections into Braces and Brackets It is also advisable to use braces or brackets to highlight important parts.   Brackets can be used if you want to mark a short passage, which is crucial for the text. In addition, these symbols are made to highlight examples that are made on the discussed point. Mark Complex Words You can also write down the words you can’t understand, making a sort of a list. You can either use sticky notes or write the words down on the margins after looking them up in the dictionary. If you find this not enough, you can even make notes on the synonyms or the most popular examples. This means that you should always have a dictionary nearby and a separate notebook for such words. Trust us, this is a great way not only to understand the book but also to improve your writing skills. Use Numbers to Highlight Points If the author supports a particular claim with several points, you can assign each of them with a number and then write those numbers on the margins. Just put numbers at the beginning of the corresponding passage. This will help you to link a particular sentence to the idea you have written down. An alternative way of using numbers is to reference pages that contain additional points on the issue. Many points that are relevant to the topic may be placed all over the book, and it can be quite difficult to find and organize them. If you notice related points on other pages, you can assign them with numbers, like ‘p7’. This means that similar information can be found on page 7. Mark Rhetorical and Literary Devices If you not only want to understand the subject but also to improve your writing, it is a great idea to assign various symbols to literary tools. In such a way you create a great basis for future research and significantly improve your writing skills. Make Comments and Ask Questions You should always keep in mind that you are an active reader, so all of the questions that pop in your head should be written down and answered. You may also have comments on different issues, and they shouldn’t be neglected. There is always plenty of space on margins, which you can use for your thoughts. Write down comments or ask questions. It can be a great way to develop the topic or to refer to other readers if you are planning to hand the book. Moreover, if you want to contact the author in the future, you will have a ready list of questions. Summarize Book’s Sections After You Have Finished the Book The bottom section of the book has plenty of space to summarize information that you have understood from the page. Start your summary with a keyword that will embody the main idea of the passage.   In addition, you can use free pages at the beginning or at the end of the book. However, don’t forget that it is a summary and summaries are always brief. Work on the Index If you start reading a book, already knowing its key themes and concepts, it will be possible to create your own index of passages and pages that correspond with these themes and concepts. Eventually, your index will be as important as the author’s one. Conclusion Annotating a book is quite a difficult process, which requires attention and time. However, it is worth it, because as a result, you get a deep understanding of the topic and improved writing and analytical skills. If the book is your property, you can use it the way you want, making notes and highlighting important sections. Even if you decide to hand it to someone else, it will be a valuable gift.